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| New Style Hydrogel Biomaterial Can Repair Knee Cartilage |
| 发布时间：2018/7/30 阅读：758次 |
It is reported by the Medical College of American Johns Hopkins University that they exploited a new style hydrogel biomaterial, which were injected in a hole of skeleton during cartilage repair surgery, and they found that this new type hydrogel biomaterial can stimulate patients’ bone marrow to create stem cells and form new cartilages. From the clinical test, the fraction of coverage of new cartilage reaches 86%, and the post operation pain will be relieved greatly. And related papers were published on the Science &Translational Medicine.
There is a thin layer of cartilage on the both side of human joint which may be damaged by such as trauma, attrition, disease or gene defect, and the cartilage will not grow voluntarily. Micro-fracture, also named arthroscopy cartilage surgery, is a surgery which stimulates bone marrow cell to create stem cells and form cartilage by drilling some small holes on the bones. But it may not be success just because of that it cannot stimulate new cartilage to grow or the new cartilage is less hard than before.
Academically, stem cells will grow well if it attaches to a nutrition holder. Gennifer Herry Sheaf, the director of TTEC, said that hydrogel holder can provide nutrition for cells during the process of bone reparation and speed up wound healing. They conducted many experiments in the laboratory in order to find a most optimal implant material. Finally, they selected a new style hydrogel biomaterial and a kind of adhesive which can make hydrogel attach to bone firmly.
Then the research group conducted clinical test for the first time, and punched some tiny holes on the bone near the damaged cartilage and put hydrogel and adhesive into the holes. And they carried out micro-fracture on the other three patients. After six months, the implants didn’t bring some big problems. The nuclear magnetic resonance show that the patient who implanted hydrogel got new cartilage and knee’s fraction of coverage reached 86%, and patients’ pain had decreased during six months after surgery.
“The pilot study showed that the implanted biomaterial behaved well in patients’ bodies as well as in laboratory, so we hope this method can be a normal measure to promote healing.” Herry Sheaf said, but this achievement still belongs to demonstration experiment, and we need much time and more test to prove the effectiveness and clinical value of hydrogel. Now, they have recruited more patients to join the further experiment.
Herry Sheaf also said that the research group was exploiting the next generation implant materials, hydrogen and adhesive were two of them, and these two materials will be integrated into one material. In addition, they were researching the technology about joint lubrication and reducing inflammation. |
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